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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
73439-19-7
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥500.0 |
| 规格： | 50 mg | 产品价格： | ￥700.0 |
| 规格： | 100 mg | 产品价格： | ￥1200.0 |
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COH-SR4
CAS No. : 73439-19-7
MCE 国际站：COH-SR4
产品活性：COH-SR4 是一种 AMPK 活化剂。COH-SR4 对白血病、黑色素瘤、乳腺癌和肺癌显示出强大的抗增殖活性。COH-SR4 通过激活 AMPK 来抑制脂肪细胞分化，有望用于肥胖及代谢紊乱相关的研究。
研究领域：Epigenetics | PI3K/Akt/mTOR
作用靶点：AMPK
In Vitro: COH-SR4 (1-5 μM; 24 hours) results in a dose-dependent increase in the phosphorylation of AMPK and its substrate ACC in 3T3-L1 preadipocytes, as well as in cancer cells such as HL-60, HeLa, MCF-7.
COH-SR4 (3-5 µM; 7 days) significantly inhibits 3T3-L1 adipocyte differentiation in a dose-dependent manner.
COH-SR4 (1-5 μM; 24 hours) promotes cell G1 cycle arrest.
COH-SR4 significantly reduces intracellular lipid accumulation and downregulates the expression of key adipogenesis-related transcription factors and lipogenic proteins.
In Vivo: COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake.
COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice.
COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice.
COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice.
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文献和实验19-20） 有时候直接洗脱到2ml Collection Tube，而不用15ml Tube。确保离心柱垂直放置不会倾覆。只有摸透了技巧才好这么弄，谢绝新手。 8. 最后异丙醇沉淀（步骤20） 从离心管中洗脱下来以后，加入异丙醇（SR4溶液）做最终沉淀。需要在-20℃孵育。此步必须在-20℃孵育（VS 室温）。此步可适当延长时间。 暂停点：若提取工作没办法继续完成，可在此步暂停过夜。样品在-20℃冷冻，RNA能稳定保存。 9. 沉淀RNA（步骤22）
PCR amplification of variable regions (SOE-Protocol)
34, 35, 36 and 37, mix) for VH amplification, CPDVHF and CPD VH Gly for chicken VH. VK front (MuPD 19, 20, 21, 22, and 23, mix) and VK back (MuPD 27, 28 and 29, mix) for VK amplification, CPDVLF and CPD VL Ser for chicken VL. Vlambda front (MuPD 26
8qoqdCv3RN/yazDp0Qt8JHmJhY+U5M19ZzQCif3ZkNE48HqYABNIEwRk8BfnGVlyIYtyCHy/u+K9qwf8QqJNTlUbBfTzI49WKn6EBbjD+TvNy7AGikbS0ESbKb9kAkwgBgKs+YgBCl9iAkwgtQjQsYsQPoI/YNfA6jh9xz10InnqYpzFGgyvkhOSuKFVCXNOV1LoJH89sMKSOecgPjRlgb/gcv8crv6sjvE7B8IkJrMThc6OB2MC6YsACx/pa794
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