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- 保存条件：
4°C, sealed storage, away from moisture and light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2023788-32-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3850.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1590.0 |
| 规格： | 5 mg | 产品价格： | ￥3500.0 |
| 规格： | 10 mg | 产品价格： | ￥5800.0 |
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Integrin modulator 1
CAS No. : 2023788-32-9
MCE 国际站：Integrin modulator 1
产品活性：Integrin modulator 1 是一种有效和选择性的 α4β1 整联蛋白激动剂，IC50 值为 9.8 nM。Integrin modulator 1 增加了 α4β1 整联蛋白介导的细胞粘附，EC50 值为 12.9 nM。
研究领域：Cytoskeleton
作用靶点：Integrin
In Vitro: Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion.
?Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells.
?Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner.
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文献和实验抗原)CD151Pt,En,Ep,G,gp27integrin粘附平滑肌细胞CD153广泛，Tgp40(TNF家族)CD30淋巴细胞间粘附(CD30L)CD154Ta(CD4+ )gp32- 39(TNF家族）CD40T- B细胞粘附(CD40L)CD162M,G,T,Bsubgp110（同源二聚体）P- selectin白细胞滚动受体(PSGL- 1) CD164M,G,Tgp80(粘蛋白样 造血细胞前体与骨髓基质细胞粘附同源二聚体)CD165Pt,T,NK,Thygp37 胸腺细胞与胸
interactions involve the simultaneous binding of two ligands to the same receptor. An allosteric modulator causes a conformational change in the receptor protein that yields a change in the binding or signaling of an orthosteric agent, i.e., an agonist
. Biol. Chem. 172, 32,719–32,722. 13. Lawson, M. A. and Maxfield, F. R. (1995) Ca2+- and calcineurin-dependent recyclingof an integrin to the front of migrating neutrophils. Nature 177, 75–79. 14. Kaverina, I., Krylyshkina, O., and Small, J. V
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