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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1253584-84-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥409.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥3200.0 |
| 规格： | 50 mg | 产品价格： | ￥5200.0 |
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NMS-E973
CAS No. : 1253584-84-7
MCE 国际站：NMS-E973
产品活性：NMS-E973 是一种有效的，可透过血脑屏障的选择性 HSP90 抑制剂。NMS-E973 与 Hsp90α 的 ATP 位点结合，DC50 小于 10 nM。NMS-E973 能够穿越血脑屏障 (BBB)。具有抗肿瘤效果。
研究领域：Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点：HSP
In Vitro: NMS-E973 inhibits cancer cell proliferation. NMS-E973 shows a widespread antiproliferative activity, with an average IC50 of 1.6 μM and 15 cell lines with an IC50 <100 nM.
In Vivo: NMS-E973 (60 mg/kg; i.v.) inhibits the growth of A375 tumors subcutaneously or intracranially implanted in mice.
NMS-E973 exhibits moderate elimination half-lives (5.55±1.07 h) due to high plasma clearance (39.9±1.70 mL/min/kg) combined with large volumes of distribution (5.83±3.18 L/kg) following intravenous administration (10 mg/kg) in mice.
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