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- 2026年05月21日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2381037-82-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4721.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1600.0 |
| 规格： | 5 mg | 产品价格： | ￥4100.0 |
| 规格： | 10 mg | 产品价格： | ￥5900.0 |
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RBN-2397
CAS No. : 2381037-82-5
MCE 国际站：RBN-2397
产品活性：RBN-2397 是一种强效的，跨物种的，且具有口服活性的 NAD+ 竞争性 PARP7 抑制剂，IC50 值小于 3 nM。RBN-2397 有选择性地结合 PARP7 (Kd=0.001 μM) 并可以恢复干扰素 I 型信号转导。RBN-2397 有潜力用于研究晚期或转移性实体肿瘤。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：PARP
In Vitro: RBN-2397 (0.0001-100 μM; 24 hours) inhibits cells? proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells.
RBN-2397 (0.4 nM-1 μM; 24 hours) shows a restoration of type I IFN response by an increase in STAT1 phosphorylation as a dose-dependent manner in NCI-H1373 human lung cancer cells.
RBN-2397 (0.0001-1 μM; 24 hours) inhibits cell MARylation in a cell biochemial assay with an EC50 value of 1 nM.
In Vivo: RBN-2397 (oral administration; 3-100 mg/kg; once daily; 24-32 days) induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses in CT26 tumor-bearing BALB/c mice.
RBN-2397 (oral administration; 3-100 mg/kg; once daily; 32 days) causes complete regressions at the dose 100 mg/kg and exerts a dose-dependent effects on tumor growth at dose levels of ≥30 mg/kg.
The half-life (t1/2) of RBN-2397 in vivo is 325 mins.
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