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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
107910-75-8
- 规格：
10 mM * 1 mL/50 mg/100 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥258.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥235.0 |
| 规格： | 100 mg | 产品价格： | ￥350.0 |
| 规格： | 500 mg | 产品价格： | ￥665.0 |
| 规格： | 1 g | 产品价格： | ￥880.0 |
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Ganciclovir sodium
CAS No. : 107910-75-8
MCE 国际站：Ganciclovir sodium
产品活性：Ganciclovir (BW 759) sodium 是一种核苷类似物和口服抗病毒活性分子，对 CMV 具有抗病毒活性。Ganciclovir sodium 在体外对疱疹病毒 (herpes group) 和其他一些 DNA 病毒也具有抗病毒活性。Ganciclovir sodium 抑制人类疱疹病毒 (HSV 1 型和 2 型，CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的体外复制。Ganciclovir sodium 对猫 1 型疱疹病毒 (FHV-1) 的 IC50 为 5.2 μM，可透过大脑屏障。
研究领域：Anti-infection | Cell Cycle/DNA Damage
作用靶点：CMV | HSV | Antibiotic | Nucleoside Antimetabolite/Analog
In Vitro: Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median Ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 μM versus 72 μM for acyclovir.
The primary mechanism of Ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase.
In Vivo: Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear.
Ganciclovir (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality.
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文献和实验• 0.1 ml 5000x Ganciclovir (use G2536 at 10 mM in PBS, P5368) • Filter-sterilize as needed, store media at 4 °C, pre-warm to 37 °C before use. 2. Cryopreservation Media Formulations 2x Freezing media preparation • 20% fetal
因子与A位结合，使合成的肽链不能从核糖体释放出来，致使核糖体循环受阻，合成不正常无功能的肽链，因而具有杀菌作用。 四、影响核酸代谢 喹诺酮类（quinolones）抑制DNA回旋酶(gyrase)，从而抑制细菌的DNA复制和mRNA的转录；利福平（rifampicin）特异性地抑制细菌DNA依赖的RNA多聚酶，阻碍mRNA的合成;核酸类似物如抗病毒药物阿糖腺苷(vidarabine)、更昔洛韦（ganciclovir）等抑制病毒DNA合成的酶，使病毒复制受阻，发挥抗病
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