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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Gentamicin C2b sulfate; Antibiotic XK-62-2 sulfate; Sagamicin sulfate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
66803-19-8
- 规格：
50 mg/100 mg
| 规格： | 50 mg | 产品价格： | ￥520.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥680.0 |
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Micronomicin sulfate
CAS No. : 66803-19-8
MCE 国际站：Micronomicin sulfate
产品活性：Micronomicin sulfate (Gentamicin C2b sulfate) 是从 Micromonospora 中分离出来的氨基糖苷抗生素 (antibiotic)。Micronomicin sulfate 是一种接近庆大霉素类抗生素的广谱抗生素，对假单胞菌、变形杆菌、肺炎克雷伯菌、沙雷菌等具有高的抑制活性 (MIC=0.001-8.3 μg/ml)。
研究领域：Anti-infection
作用靶点：Antibiotic | Bacterial
In Vitro: Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).
In Vivo: Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD50 in mice of 93 mg/kg.
Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.
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文献和实验Metabolic Labeling with Sulfate
of proteins make it possible to determine where a protein normally resides or to follow its transport through the cell. One such modification is addition of sulfate either to tyrosine residues or to carbohydrate side chains. Labeling studies with [35 S
Ammonium Sulfate Binding Assay for Cells
1. Resuspend cells (vegetative or developed) in phosphate buffer at 1 x 10 8 /ml . 2. Add 50 ul cells to 50 ul 20 nM 3H-cAMP in 5-10 mM DTT (for background binding, add same amount of hot cAMP plus 10 uM cold cAMP) in 1.5 ml eppendorf tube
在哺乳动物真皮中发现的一种粘多糖。在真皮中，于成熟的胶原纤维丰富的层中，以蛋白多糖即以与蛋白质相结合的（蛋白硫酸皮肤素）形式而存在。因此胶原分子是按一定的空间排列集成，并由桥键组成纤维构造，而蛋白硫酸皮肤素具有重要作用。除皮肤以外，也可从大动脉、脐带、腱、心脏瓣膜、肝脏和半月瓣等分离出来，而在鼻软骨和骨端软骨中并不存在。化学构造如图所示是 L-艾杜糖醛酸和 N-乙酰半乳糖胺 -4-硫酸所形成的二糖单位的重复结构而为其主体，但糖醛酸的一部分为艾杜糖
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