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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
BTS 40542
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
67747-09-5
- 规格：
10 mM * 1 mL/250 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 250 mg | 产品价格： | ￥500.0 |
| 规格： | 500 mg | 产品价格： | ￥800.0 |
| 规格： | 1 g | 产品价格： | ￥1200.0 |
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Prochloraz
CAS No. : 67747-09-5
MCE 国际站：Prochloraz
产品活性：Prochloraz 是一种咪唑类抗真菌剂。Prochloraz 是雌激素受体 (ER) 和雄激素受体 (AR) 拮抗剂以及芳香酶 (aromatase) 抑制剂，IC50 值分别为 25 μM、4 μM 和 0.3 μM。Prochloraz 也能够激活芳烃受体 (AhR)，EC50 为 1 μM。
研究领域：Anti-infection | Vitamin D Related/Nuclear Receptor | Immunology/Inflammation
作用靶点：Fungal | Estrogen Receptor/ERR | Androgen Receptor | Aryl Hydrocarbon Receptor
In Vitro: Prochloraz has a strong inhibition of the microsomal cytochrome P-450 dependent 14α-demethylation of lanosterol during ergosterol biosynthesis, which leads to membrane disruption and eventually to cell death.
In Vivo: In vivo Prochloraz acts as an antiandrogen in the Hershberger assay by reducing weights of reproductive organs, affecting androgen-regulated gene expressions in the prostate and increasing luteinizing hormone levels. In order to investigate the developmental effects of Prochloraz, pregnant Wistar dams were dosed perinatally with 30 mg/kg Prochloraz. Results show that Prochloraz significantly reduces plasma and testicular testosterone levels in gestational day 21 male foetuses, whereas testicular progesterone was increased. Gestational length is increased by Prochloraz.
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