Tigecycline,1229002-07-6

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Tigecycline hydrate

CAS No. : 1229002-07-6

MCE 国际站：Tigecycline hydrate

产品活性：Tigecycline (GAR-936) hydrate 是一种广谱的甘氨酰环素抗生素。Tigecycline hydrate 对 E. coli (MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/mL。对 Acinetobacter baumannii (A. baumannii) 的 MIC₅₀ 和 MIC₉₀ 分别为 1 和 2 mg/L。

研究领域：Anti-infection  |  Autophagy

作用靶点：Bacterial  |  Autophagy  |  Antibiotic

In Vitro: Tigecycline (0.63-30 µM, preincubated for 4 days, treated for 72 h) hydrate inhibits AML2 cells and HL-60 cells with IC₅₀s of 4.72 and 3.06 μM (freshly prepared).

In Vivo: Tigecycline (50 mg/kg; intraperitoneal injection; twice a day; for 11 days) hydrate reduces tumor volume and weight in NOD/SCID mice.
The peak plasma concentration (C_max), the terminal half-life (t_1/2), area under the plasma concentration-time curve (AUC), clearance (CL) and volume of distribution (Vz) are 22.8μg/mL, 108.9 min, 1912.2min*μg/mL, 26.1 mL/min/kg, 4109.4 mL/kg for Tigecycline hydrate in saline, respectively.

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