AzddMeC,87190-79-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AzddMeC

CAS No. : 87190-79-2

MCE 国际站：AzddMeC

产品活性：AzddMeC (CS-92) 是一种抗病毒核苷类似物，也是一种有效的，选择性的，具有口服活性的 HIV-1 逆转录酶和 HIV-1 复制的抑制剂。在感染 HIV-1 的人类 PBM 细胞和感染 HIV-1 的人类巨噬细胞中，AzddMeC 的 EC₅₀ 值分别为 9 nM 和 6 nM。AzddMeC 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage

作用靶点：HIV  |  Reverse Transcriptase  |  Nucleoside Antimetabolite/Analog

In Vitro: AzddMeC (CS-92) is also effective against HIV-2 in lymphocytes. The replication of Friend murine virus is only weakly inhibited, and no effect is observed against HSV type 1 and type 2 and coxsackievirus B4. The interaction of the 5'-triphosphate of AzddMeC with HIV-1 reverse transcriptase indicated competitive inhibition (the inhibition constant, Kis, is 9.3 nM).

In Vivo: The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%.

相关产品：Natural Product-like Compound Library  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Antiviral Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Nucleotide Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  Cytokine Inhibitors Library  |  Chloroquine  |  Doxorubicin hydrochloride  |  5-Fluorouracil  |  Gemcitabine  |  Decitabine  |  5-Azacytidine  |  Cytarabine  |  5-BrdU  |  Q-VD-OPh  |  Valproic acid  |  Fludarabine  |  Panobinostat  |  Shikonin  |  Hydroxyurea  |  Probenecid  |  Kaempferol  |  Plerixafor  |  Dimethyl fumarate  |  Birinapant  |  Maraviroc  |  Capecitabine  |  Adenosine  |  Baicalin  |  Flavopiridol  |  Ritonavir  |  Uridine  |  Ivermectin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds