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- 2025年12月05日
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- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1410809-37-8
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5658.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2240.0 |
| 规格： | 5 mg | 产品价格： | ￥5320.0 |
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ACHN-975 TFA
CAS No. : 1410809-37-8
MCE 国际站：ACHN-975 TFA
产品活性：ACHN-975 是细菌酶 LpxC 的选择性抑制剂，表现出亚纳摩尔级 LpxC 抑制活性。ACHN-975 对多种革兰氏阴性菌的 MIC 值低于 1 μg/mL。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: ACHN-975 is against Enterobacteriaceae spp with an IC50 of 0.02 nM.
ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively.
ACHN-975 is potently against the P. aeruginosa isolates tested, inhibiting 100% of the isolates at an MIC of ≤2 μg/ml. It against Pseudomonas aeruginosa with an MIC50 and MIC90 of 0.06 and 0.25 μg/ml, respectively.
ACHN-975 is against six P. aeruginosa isolates, it against P. aeruginosa APAE1064, APAE1232, and APAE1064 isolates with MIC values of 0.12, 0.06 and 0.06 μg/ml, respectively.
LpxC is highly conserved in gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
In Vivo: ACHN-975 TFA (intraperitoneal administration; 5-30 mg/kg; single dose) leads to a steady reduction in bacterial titers in the first 4 h following treatment for all dosing groups. The sampling shows that the level of free drug in this model drops below the ACHN-975 MIC for this isolate (0.25 μg/ml) by 2 h after treatment with the 10 mg/kg dose and by 4 h after treatment with the 30 mg/kg dose.
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文献和实验Culturing Worms by Michael Koelle 1. Bacterial strain for feeding worms: OP50, a uracil auxotroph. Streak OP50 out on a 9 cm NGM agar plate , grow overnight at 37°. Can then parafilm the plate and keep it at 4° for months
Culturing Worms by Michael Koelle 1. Bacterial strain for feeding worms: OP50, a uracil auxotroph. Streak OP50 out on a 9 cm NGM agar plate , grow overnight at 37°. Can then parafilm the plate and keep it at 4°
4.2mg，合计12.2mg ；对照地区相应为0.96mg和3.9mg。 经调查饮用温泉水地区居民斑釉齿患病率64.2%，对照地区9.1%；而患龋率两地区分别为14.5%有26.0%。 X线片检查95名对照居民未发现骨异常，74名温泉水地区居民中发现可疑骨异常6例，早期氟骨症9例，Ⅰ期氟骨症8例，氟骨症患病率23.0%，患者均为当地出生并一直饮用温泉水的农民。 饮用温泉水975名居民尿氟测定，中位数为1.86mg/L，95%可信限上限值为7.77
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