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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1445790-55-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1650.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥681.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2300.0 |
| 规格： | 25 mg | 产品价格： | ￥4500.0 |
| 规格： | 50 mg | 产品价格： | ￥6800.0 |
| 规格： | 100 mg | 产品价格： | ￥9800.0 |
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NVR 3-778
CAS No. : 1445790-55-5
MCE 国际站：NVR 3-778
产品活性：NVR 3-778 是一种首创、口服有效的 HBV CAM (衣壳组装调制剂)，属于 SBA 类，具有抗 HBV 活性。
研究领域：Anti-infection
作用靶点：HBV
In Vitro: NVR 3-778 targets HBV core protein and inhibits viral replication.
NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral with an EC50 of 0.40 µM in HepG2.2.15 cells.
NVR 3-778 exhibits pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication.
NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles.
NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81 µM against HBV DNA and between 3.7µM and 4.8 µM against the production of HBV antigens and intracellular HBV RNA.
The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively.
In Vivo: NVR 3-778 (1.5 mg/kg; i.g.) displays the mean Cmax and AUC0–inf values of 0.56 µg/ml and 3.50 µg·h/ml, respectively, in dogs following oral administration. And the mean oral bioavailability is determined to be 84.6%.
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文献和实验Mixed Infections with Rotaviruses: Protocols for Reassortment, Complementation, and Other Assays
of the interactions. Here, methods for mixed infections between conditional-lethal mutants of the temperature-sensitive (ts ) phenotype will be presented and considered. (Mutants with ts phenotype are designated according to the following nomenclature: ts A [778
, where tissue autofluorescence is minimal. Here we describe the manufacture of 12-nm 3-dimercaptosuccinic acid-coated Fe3 O4 magnetic nanoparticles, their labeling with a new near-infrared fluorophore, IRDye800CW (excitation/emission: 778/806 nm
Reynolds, EA Greene, C Codomo, L Enns, J Johnson, C Burtner, A Odden, K Young, and S Henikoff. 2004. Large-scale discovery of natural polymorphisms by Ecotilling. Plant Journal 37:778-786
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