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文献和实验Protein-Deoxyribonucleic Acid Interactions Linked to Gene Expression: DNase I Digestion
) can be identified. A major strength of this method is that it is an “unbiased” approach to characterize the location of control sequences for the regulation of a gene. A good example of the power of DNase I hypersensitivity mapping is the rat
Streptozotocin, Type I Diabetes Severity and Bone
to spontaneously diabetic mouse and rat models and to human T1 diabetic bone pathology. Specifically, bone volume, mineral apposition rate, and osteocalcin serum and tibia messenger RNA levels are decreased. In contrast, bone marrow adiposity and aP2 expression
Analysis of Antibody-Antigen Interactions Using Surface Plasmon Resonance
currently exist for measuring antibody-antigen interactions to include enzyme immunoassays (EIA), Western blotting, radioimmunoassays, and others. However, these techniques all require some form of protein labeling or secondary antibodies for detection of specific
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