Anti-FGFR4 Polyclonal Antibody

产品简介

英文名称	Anti-FGFR4 Polyclonal Antibody
宿主	Rabbit
别名	FGFR4;CD334;JTK2;TKF;fibroblast growth factor receptor 4
稀释比例	WB 1:5000-8000. IHC 1:100-300.
蛋白分子量	64/83/87kDa
Gene ID	2264
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human FGFR4
亚细胞定位	Cytoplasm Cell membrane
Swiss Prot	P22455
背景资料	The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Public Immunogen Range	125-175/802aa
克隆类型	Polyclonal Antibody
交叉反应	Human
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with FGFR4 antibody diluted at 1:6000;Lane: Rat lung,Rat liver,Raji

Immunohistochemistry?of?paraffin-embedded?Human thyroid cancer?with?FGFR4 antibody diluted at