Immortalised human epithelial cell line (A2EN; passage >50) derived from human primary epithelial cells expanded from an explant of human endocervical tissue.The endocervical epithelium is a single cell layer lining the endocervical canal that separates the lower female reproductive tract from the uterus and Fallopian tubes. Endocervical epithelial cells secrete mucus and innate immune mediators that facilitate reproduction as well as protect from pathogen invasion. The endocervix is a major site of transmission for multiple sexually transmitted organisms, such as Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Human Immunodeficiency Virus (HIV).永生化人上皮细胞系(A2EN;原代上皮细胞来源于人宫颈内组织的外植体。宫颈内上皮是一种单层细胞层,衬里宫颈内管,它将女性生殖道下部与子宫和输卵管分开。宫颈上皮细胞分泌黏液和先天免疫介质,促进生殖,并保护病原体的入侵。宫颈内是多种性传播生物的主要传播部位,如沙眼衣原体、淋病奈瑟菌、生殖道支原体和人体免疫缺陷病毒(HIV)。