Recombinant Human CD147 Protei

产品概述（Summary）

产品名称（Product name）
Recombinant Human CD147 protein

货号（Catalog#）
ATAP00046

描述（description）
Recombinant Human CD147 is produced by E.coli expression system and the target gene encoding Ala22-Ala207 is expressed with His Tag

表达系统（Expression system）
E.coli

种属（Species）
Homo sapiens (Human)
Accession #
P35613

别名（Alternative names)
5F7 Protein, Human; Basigin Protein, Human; CD147 Protein, Human; EMMPRIN Protein, Human; M6 Protein, Human; OK Protein, Human; TCSF Protein, Human

预测分子量（Predicted Molecular Mass）
22.59 kDa

纯度（Purity）
>90% as determined by SDS-PAGE

内毒素（Endotoxin level）
Please contact with the lab for this information

制剂（Formulation）
Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5

运输方式（Shipping）
In general, proteins are shipped out with blue ice unless customers require otherwise.

稳定性&储存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶（Reconstitution）
Please refer to the instraction in the hard copy of COA.

应用（Application）
Immunogen

电泳图（SDS-PAGE image）

活性（Bioactivity）

背景（Background）
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.