- ￥585
- Sigma-Aldrich
- 进口
- K1128-25G
- 2025年11月14日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
α-Ketoglutaric acid
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
328-50-7
- 规格：
25G
属性
产品线
BioReagent
质量水平
200
方案
≥98.5% NaOH basis (titration)
表单
powder or crystals
技术
cell culture | insect: suitable
cell culture | mammalian: suitable
溶解性
water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
储存温度
2-8°C
SMILES字符串
OC(=O)CCC(=O)C(O)=O
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
一般描述
应用
- 作为最低基础培养基α (α-MEM)的补充剂，培养原代间充质基质细胞/干细胞 (MSC)， 以研究其对年龄相关性骨质疏松症的影响
- 化学治疗，以在手动和自动寿命机器 (ALM) 平台之间，比较几种化合物对寿命的治疗效果
- 用作打印趋化因子配体，使用高通量技术筛选趋化因子受体并验证与表面等离子体共振 (SPR) 的相互作用
生化/生理作用
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations.
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends the lifespan of worms and maintains the pluripotency of embryonic stem cells (ESCs). Here, we show that the administration of αKG increases the bone mass of aged mice, attenuates age-related bone loss, and accelerates bone regeneration of aged rodents. αKG ameliorates the senescence-associated (SA) phenotypes of bone marrow MSCs derived from aged mice, as well as promoting their proliferation, colony formation, migration, and osteogenic potential. Mechanistically, αKG decreases the accumulations of H3K9me3 and H3K27me3, and subsequently upregulates BMP signaling and Nanog expression. Collectively, our findings illuminate the role of αKG in rejuvenating MSCs and ameliorating age-related osteoporosis, with a promising therapeutic potential in age-related diseases.
技术资料暂无技术资料 索取技术资料
