- ￥1635
- Sigma-Aldrich
- 进口
- 77332-100MG
- 2025年10月21日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Peroxidase from horseradish
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
9003-99-0
- 规格：
100MG
属性
生物来源
horseradish
表单
powder
质量
lyophilized
比活
~150 U/mg
分子量
Mr ~40000
溶解性
50 mM potassium phosphate buffer, pH 6.0: 5 mg/mL (0.1% BSA)
运输
wet ice
储存温度
2-8°C
SMILES字符串
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
InChI key
JSPLKZUTYZBBKA-UHFFFAOYSA-N
一般描述
应用
- 用于分离N-连接的聚糖
- 作为D-氨基酸氧化酶（DAAO）的成分缓冲区
- 将过氧化氢（H2O2）分解为水，以证明便携式氧化应激传感器（POSS）的性能
其他说明
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文献和实验Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier.
The blood-brain barrier (BBB) restricts clinically relevant accumulation of many therapeutics in the CNS. Low-dose methamphetamine (METH) induces fluid-phase transcytosis across BBB endothelial cells in vitro and could be used to enhance CNS drug delivery. Here, we show that low-dose METH induces significant BBB leakage in rodents ex vivo and in vivo. Notably, METH leaves tight junctions intact and induces transient leakage via caveolar transport, which is suppressed at 4°C and in caveolin-1 (CAV1) knockout mice. METH enhances brain penetration of both small therapeutic molecules, such as doxorubicin (DOX), and large proteins. Lastly, METH improves the therapeutic efficacy of DOX in a mouse model of glioblastoma, as measured by a 25% increase in median survival time and a significant reduction in satellite lesions. Collectively, our data indicate that caveolar transport at the adult BBB is agonist inducible and that METH can enhance drug delivery to the CNS.
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