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- Sigma-Aldrich
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- 2025年09月11日
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- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
Ciprofloxacin
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
85721-33-1
- 规格：
5G
属性
Agency
EPA 1694
质量水平
200
方案
≥98% (HPLC)
表单
powder or crystals
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
应用
environmental
作用机制
DNA synthesis | interferes
enzyme | inhibits
SMILES字符串
OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI
1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
InChI key
MYSWGUAQZAJSOK-UHFFFAOYSA-N
基因信息
human ... CYP1A2(1544), KCNH1(3756)
rat ... Gabra1(29705)
一般描述
化学结构：氟喹诺酮
应用
生化/生理作用
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文献和实验Ciprofloxacin derivatives and their antibacterial activities.
Bacterial infections represent a significant health threat globally, and are responsible for the majority of hospital-acquired infections, leading to extensive mortality and burden on global healthcare systems. The second generation fluoroquinolone ciprofloxacin which exhibits excellent antimicrobial activity and pharmacokinetic properties as well as few side effects is introduced into clinical practice for the treatment of various bacterial infections for around 3 decades. The emergency and widely spread of drug-resistant pathogens making ciprofloxacin more and more ineffective, so it's imperative to develop novel antibacterials. Numerous of ciprofloxacin derivatives have been synthesized for seeking for new antibacterials, and some of them exhibited promising potency. This review aims to summarize the recent advances made towards the discovery of ciprofloxacin derivatives as antibacterial agents and the structure-activity relationship of these derivatives was also discussed.
0.3%的盐酸CPFX溶液，再制成每克纱条含主药10mg的凡士林纱条。临床用于乳突根治术患者33例，其中胆脂瘤型中耳乳突炎22例、坏死型中耳乳突炎11例。结果：治愈25例，好转6例，无效2例，总有效率为94%。该法没有碘仿纱条的不良臭味，是目前临床较满意的替代制剂。 14 凝胶剂 薛大权等〔20〕以CPFX0.3g，聚羧乙烯941 0.5g，乙醇3g，甘油5g，三氯叔丁醇0.1g，三乙醇胺适量，蒸馏水加至100g制成CPFX凝胶剂。临床上直接涂敷于疾患处，主要用于敏感性致病菌引起的皮肤
mM TrisCl 6.057g Chromogenic solution 33ulNBT solution 33ulBCIP solution 10ml alkaline phosphatese buffer NBT solution:0.1g NBT in 10ml 70% N,N-dimethylformamide BCIP solution:0.5g BCIP in 10ml N,N-dimethylformamide Alkaline Phosphatese buffer 1L
, incubate for 30 min at 37°C. ( 5g powdered milk in 95 ml PBS)5 Rinse with PBS 3x.6 Add 50 µl of antibody, incubate 30 min at 37°C.7 Rinse with PBS 3x.8 Add 50 µl of goat anti-mouse IgG conjugate with alkaline phosphatase.(1 µl of conjugate in 4 ml of PBS
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