- ￥444
- Sigma-Aldrich
- 进口
- 01897-250MG
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Adenosine 5′-diphosphate disodium salt
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
16178-48-6
- 规格：
250MG
属性
方案
≥90%
表单
powder or crystals
旋光性
[α]20/D −29.6±1°, c = 0.5% in 0.5 M Na2HPO4
杂质
≤10% water
储存温度
−20°C
SMILES字符串
[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
InChI
1S/C10H15N5O10P2.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
InChI key
ORKSTPSQHZNDSC-IDIVVRGQSA-L
应用
生化/生理作用
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文献和实验Protective effects of fisetin against myocardial ischemia/reperfusion injury.
The underlying mechanism of the myocardial protective effect of fisetin was studied in a rat ischemia/reperfusion injury model. Sprague-Dawley rats were randomly assigned to seven groups and pretreated with different solutions by gavage administration. A rat model of cardiac ischemia/reperfusion injury was established. Plasma levels of Von Willebrand factor (vWF) were determined by ELISA, flow cytometry was used to determine the level of cardiomyocyte apoptosis and 2,3,5-triphenyltetrazolium staining was used to determine the size of myocardial infarcts. Hematoxylin and eosin-stained sections of myocardial tissues were examined for pathological changes. Expressions of nuclear factor (NF)-κB and matrix metallopeptidase 9 (MMP-9) were measured by immunohistochemistry. Compared with the model group, rats pretreated with fisetin, quercetin and aspirin showed significant prolongation of clotting time, prothrombin time, thrombin time and activated partial thromboplastin time. Fisetin treatment better maintained the integrity of myocardial fibers and nuclear integrity, reduced the percentage of apoptotic myocardial cells, inhibited expression of NF-κB, decreased the loss of MMP-9 and reduced nuclear translocation of NF-kB. Rats pretreated with fisetin also demonstrated a significant decrease in plasma levels of vWF. In addition, the protective effect of fisetin on myocardial cells was found to be dose dependent.
疟原虫 Malaria Parasites(Plasmodium)
vials for intravenous use): for severe malaria 120mg I.V. stat. 60 mg at 4, 24 and 48 hours, 50-60 mg on days 3-5. Give mefloquine as above.Dihydroartemisinin (20 mg tablets): first dose 120mg then 60mg daily for 4-6 days then give mefloquine
Establishment of Stable Transfectant of CHO Lec Cells
medium: To 9 lt of mili-Q water, add MEM w/o Gln (GIBCO, #11700-077). Pwdr for 10 lt.NaHCO3 , 27.75gglucose: 30 gnucleosides: adenosine (Sigma A-4036), 70mg; guanosine (Sigma G-6264), 70mg; cytidine (Sigma C-4654), 70mg; uridine (Sigma U
Establishment of Stable Transfectant of CHO Lec Cells
) by yourself but this cannot be used as serum-free medium. Recipe for 10 lt of J/J medium: To 9 lt of mili-Q water, add MEM w/o Gln (GIBCO, #11700-077). Pwdr for 10 lt. NaHCO3 , 27.75g glucose: 30 g nucleosides: adenosine (Sigma A-4036), 70mg
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