- ￥240
- Sigma-Aldrich
- 进口
- I0125-10G
- 2025年07月12日
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- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
Imidazole
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
288-32-4
- 规格：
10G
属性
等级
reagent grade
蒸汽压
<1 mmHg ( 20 °C)
方案
≥98.5% (titration)
表单
crystalline
杂质
~0.3% Fluorescence blank (β-NADH equivalence.)
颜色
white to off-white
pKa (25 °C)
6.95
沸点
256 °C (lit.)
mp
88-91 °C (lit.)
SMILES字符串
c1c[nH]cn1
InChI
1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI key
RAXXELZNTBOGNW-UHFFFAOYSA-N
应用
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文献和实验Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.
Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesized from isoleucine and acetoacetyl-coenzyme A by TeA synthetase 1 (TAS1). TAS1 is a unique non-ribosomal peptide synthetase and polyketide synthase (NRPS-PKS) hybrid enzyme that begins with an NRPS module. In contrast to other NRPS/PKS hybrid enzymes, the PKS portion of TAS1 has only a ketosynthase (KS) domain and this domain is indispensable for TAS1 activity. Phylogenetic analysis classifies this KS domain as an independent clade close to type I PKS KS domain. We demonstrate that the TAS1 KS domain conducts the final cyclization step for TeA release. These results indicate that TAS1 is a unique type of NRPS-PKS hybrid enzyme.
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