SIGMA G8294-100UG Anti-Gonadot
ropin Releasing Hormone(GnRH)antibody produced in rabbit- ￥5285
- Sigma-Aldrich
- 进口
- G8294-100UG
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
见瓶身
- 规格：
100UG
属性
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse
技术
immunohistochemistry: 1 μg/mL using mouse embryo brain
UniProt登记号
P13562
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GNRH1(2796)
mouse ... Gnrh1(14714)
rat ... Gnrh1(25194)
免疫原
应用
Immunocytochemistry (1 paper)
生化/生理作用
外形
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文献和实验SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders. CRISPR/Cas9-mediated alteration of smchd1 in zebrafish yielded arhinia-relevant phenotypes. Transcriptome and protein analyses in arhinia probands and controls showed no differences in SMCHD1 mRNA or protein abundance but revealed regulatory changes in genes and pathways associated with craniofacial patterning. Mutations in SMCHD1 thus contribute to distinct phenotypic spectra, from craniofacial malformation and reproductive disorders to muscular dystrophy, which we speculate to be consistent with oligogenic mechanisms resulting in pleiotropic outcomes.
祝贺〖雅裕睿安〗成为Signalway Antibody(SAB)独家
Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ß-Subunit Genes in Immature Gonadotropes'' and Their Actions Are Overcome by Gonadotropin-Releasing Hormone.Molecular and Cellular Biology'' 27(11):4105-4120
secondary antibody review -- data from 99 publications
cytometry used as a control to detect cell responses targeted antigen 7 Alexa Fluor 488 7 Cy3 8 goat IgG Alexa Fluor 488 1:2000 detect antibody binding in human embryonic kidney 293T cells Invitrogen 9 donkey
The production of monoclonal antibody by hybridoma
. Keywords: monoclonal antibody ; hybridoma ; fusion Reference 1) Kohler G, and C. Milstein Continuous cultures of fused cells secreting
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