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Anti-Amyloid, beta 1-42; 50 μg

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  • 询价
  • AB5078P
  • 2025年12月31日
  • ELISA;Western Blotting
  • Rabbit
  • Chicken;Human;Mouse
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 应用范围：

      ELISA;Western Blotting

    • 宿主：

      Rabbit

    • 适应物种：

      Chicken;Human;Mouse

    • 库存：

      大量

    • 抗原来源：

      0

    • 是否单克隆：

      2

    • 规格：

      50 μg

    Product Images

    Immunohistochemistry (Paraffin) Analysis:
    Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Alzheimer’s Disease-Brain
    Beta-Am...

    Immunohistochemistry (Paraffin) Analysis:
    Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Alzheimer’s Disease-Brain
    Beta-Am...
    Species Reactivity Key Applications Host Format Antibody Type
    Ch, H, M ELISA, IH, IH(P), WB Rabbit Affinity Purified Polyclonal Antibody
    Description:
    Anti-Beta-Amyloid 1-42
    Background Information:
    The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.
    Specificity:
    Recognizes beta-amyloid 1-42. Antibody does not show appreciable reactivity with beta amyloid 1-40 as detected by ELISA.
    One of the most important and initial steps which causes loss of memory and cognition in Alzheimer’s Disease (AD) involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 amino acid peptides (beta amyloid 1-40, 1-42 and 1-43). Polymerization of beta-amyloid and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition.
    Key Applications:
    • ELISA
    • Immunohistochemistry
    • Immunohistochemistry (Paraffin)
    • Western Blotting
    Application Notes:
    Immunohistochemistry (Paraffin) Analysis:

    Western Blot:
    1-10 µg/mL of a previous lot was used. (Chemiluminescence technique).

    ELISA:
    1:10,000-1:100,000 of a previous lot was used using 50-100 ng immunogen peptide/well.

    Optimal working dilutions must be determined by the end user.
    Species Reactivity:
    • Chicken
    • Human
    • Mouse
    Species Reactivity Note:
    Human.
    Immunogen:
    A six amino acid peptide sequence from the C-terminal of human beta-amyloid 1-42.
    Epitope:
    C-terminus
    Control:
    Alzheimer's disease brain tissue, whole tissue extracts from mouse brain. C03-801.
    Presentation:
    Purified rabbit polyclonal in liquid buffer containing PBS with 0.1% BSA.
    Storage Conditions:
    Stable for 1 year at -20ºC from date of receipt.
    Gene Symbol:
    • APP
    • PN-II
    • AD1
    • ABETA
    • CTFgamma
    • APPI
    • ABPP
    • A4
    • CVAP
    • PN2
    • PreA4
    • AAA
    Quality Assurance:
    Routinely evaluated by immunohistochemistry (paraffin) on Alzheimer’s Disease-Brain.

    Immunohistochemistry (Paraffin) Analysis:
    Beta-Amyloid (cat. # AB5078P) staining on Alzheimer’s Disease-Brain. Tissue pretreated with Citrate, pH 6.0. The antibody was diluted to 1:35, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as staining on plaque deposits (brown) or as cerebral vascular amyloid deposition in the walls of blood vessels (brown).
    Antibody Category:
    Neuroscience
    Antibody Sub-Category:
    Neurodegenerative Diseases
    Usage Statement:
    Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    Trade Name:
    Chemicon (Millipore)
    Format:
    Affinity Purified
    Host:
    Rabbit
    Concentration:
    1 mg/mL
    Antibody Type:
    Polyclonal Antibody

    更多产品技术资讯，请访问密理博中国博客：http://blog.milliporechina.com

    A 6 amino acid peptide sequence from the C-terminal of human beta-amyloid 1-42. 详细描述见链接：http://www.millipore.com/catalogue/item/AB5078P

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