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文献和实验Microextrusion Printing Cell-Laden Networks of Type I Collagen with Patterned Anisotropy and Geomtery. (2019).Acta Biomaterialia
Tissue-mimicking gelatin scaffolds by alginate sacrificial templates for adipose tissue engineering. (2019).Acta Biomaterialia
Mouse in vitro spermatogenesis on alginate-based 3D bioprinted scaffolds. (2019).Biofabrication
Extrusion-based printing of sacrificial Carbopol ink for fabrication of microfluidic evices (2019).Biofabrication
Process- and bio-inspired hydrogels for 3D bioprinting of soft free-standing neural and glial tissues. (2019). Biofabrication
Formulation and Characterization of a SIS-Based Photocrosslinkable Bioink. (2019).Polymers
Multi-channel silk sponge mimicking bone marrow vascular niche forplatelet production.(2018).Biomaterials
Mechanical behaviour of alginate-gelatin hydrogels for 3D bioprinting. (2018). Journal of the mechanical behavior of
biomedical materials
3D Bioprinting and Stem Cells .(2018). Somatic Stem cells
3D printing of PDMS improves its mechanical and cell adhesion properties Skin Grafting on 3D Bioprinted Cartilage Constructs In Vivo. (2018). ACS Biomaterials Science & Engineering
Bioprinted (3D) co-cultured spheroids with NSCLC PDX cells and cancer associated fibroblasts (CAFs) using alginate/gelatin hydrogel.(2018) .AACR, Cancer research
Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus.(2018).Scientific reports
Fabrication of naftopidil-loaded tablets using a semi-solid extrusion-type 3D printer, and the characteristics of the printed hydrogel and resulting tablets. (2018). Journal of pharmaceutical sciences
High-resolution patterned cellular constructs by droplet-based 3D printing. (2017). Scientific reports
Combination of CDODA-Me, a glycyrrhetinic acid derivative, and Erlotinib overcomes chemo-resistance in NSCLC PDX spheroids and 3D bio-printed cells.
(2017).AACR, Cancer Research.
Controlling adult stem cell behavior using nanodiamond-reinforced hydrogel: Implication in bone regeneration therapy. (2017).Scientific Reports
Increased lipid accumulation and adipogenic gene expression of adipocytes in 3D bioprinted nanocellulose scaffolds. (2017). Biofabrication
何为 3D 生物打印? 3D 生物打印指通过设计类组织复杂程度的体模形基质,生成精确控制的 3D 细胞模型和组织结构。由于底物与成分高度可控,3D 生物打印有望满足许多药物研究未竞的关键需求,包括在化妆品检测、药物研究、再生医药和功能性器官置换等应用领域的需求。使用诱导性多能干细胞(iPS 细胞)或间充质干细胞等患者源性干细胞可以创造出个性化的疾病模型。根据具体应用,可通过一系列材料、方法和细胞创造理想的组织结构(图 1)。 图1.组织与器官的3D生物打印。生物墨水通过结合培养
人体器官首次达成透明化!有望实现「人造器官」的 3D 生物打印
近年来,组织工程致力于通过人体器官组织的细胞图谱,结合 3D 生物打印等新兴技术复制人体组织和器官。准确绘制完整的人体器官大多受限于解剖结构复杂性和细胞水平成像技术尚未成熟。德国亥姆霍兹慕尼黑中心组织工程和再生医学研究所、慕尼黑大学、慕尼黑工业大学联合团队利用 SHANEL(Small-micelle-mediated Human orgAN Efficient clearing and Labeling 小胶束介导的人体器官透明和标记)组织学方法呈现了完整人体器官在细胞水平上的复杂结构
Science:3D 基因组学揭示两种细胞核类型相互转换机制!
territorialization 的关键因素,那么凝缩蛋白 I 的缺失是否也会产生影响呢?然而研究结果发现凝缩蛋白 I 亚基 CAP-H 的缺失并不会导致着丝粒聚集。研究总结本研究发现了两种类型的 3D 基因组结构,每种类型在真核生物进化过程中反复出现和消失。并表明基因组结构类型的转换与凝缩蛋白 II 亚基的缺失有关。研究人员进一步提出了一个物理模型,认为有丝分裂期间凝缩蛋白 II 对染色体的纵向压缩决定了染色体尺度上的基因组结构,其影响在随后的间期中被保留。并且推测这种机制可能从所有真核生物的最后一个共同祖先开始就被保











