- ￥417 - 1820
- TargetMol
- 美国
- T5784
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Topotecan
- 库存：
10
- 供应商：
TargetMol
- CAS号：
123948-87-8
- 规格：
10 mg/25 mg/100 mg
| 规格： | 10 mg | 产品价格： | ￥417.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥734.0 |
| 规格： | 100 mg | 产品价格： | ￥1820.0 |
Product Introduction
Bioactivity
英文名:Topotecan
描述:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
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文献和实验Purification of DNA Topoisomerase I from Human Placenta
DNA topoisomerase I (topo I) has been firmly established as the molecular target of the camptothecin group of anticancer drugs. These drugs include camptothecin, topotecan, 9-amino-camptothecin, and irinotecan
Cytometric Assessment of DNA Damage Induced by DNA Topoisomerase Inhibitors
with the cell cycle phase or DNA ploidy. The protocol can also be used to assess activation (Ser- 1981 phosphorylation) of ATM; this event also revealing DNA damage induced by topo I or topo II inhibitors. Examples where DNA damage was induced by topotecan (topo
Detection of DNA Strand Breaks in Apoptotic Cells by Flow- and Image-Cytometry
one to correlate the induction of apoptosis with the cell cycle phase. Examples of the detection of apoptotic cells in cultures of human leukemic cell lines treated with TNF-α and DNA topoisomerase I inhibitor topotecan are presented. The protocol can be applied
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