Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
形态:
Liquid
亚型:
IgG
免疫原:
The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
规格:
50μl/100μl
规格:
50μl
产品价格:
¥1500.0
规格:
100μl
产品价格:
¥2500.0
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol. domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA. Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Belongs to the peptidase M67A family. MYSM1 subfamily. Contains 1 MPN (JAB/Mov34) domain. Contains 1 SANT domain. Contains 1 SWIRM domain. subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.