N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified using glutathione- agarose.
Contains the gatekeeper mutation T160M in the ATP-binding domain. This mutation increases resistance to SB203580 as compared to the wild type sequence.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Species:
Human
Molecular Weight:
67.7kDa
Quality Assurance:
routinely evaluated by phosphorylation of MBP (13-104).
Therapeutic Areas:
Inflammation
Source:
Human, full-length p38α/SAPK2a containing the mutation T106M. Expressed in E. coli.
Storage Conditions:
1 year at -20°C from date of shipment
Specific Activity:
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.