WS6

一种化合物，能够刺激大鼠和人类原代胰岛的胰岛β细胞增殖（ECmax分别为200和400 nM，在四天内）；在体内促进β细胞生长，增加β细胞质量，并在RIP-DTA小鼠模型中恢复β细胞缺失后的血糖水平。A compound that stimulates the proliferation of pancreatic β cells rodent and human primary islets (ECmax = 200 and 400 nM, respectively, over four days); promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.