BAY u9773

CysLT1和CysLT2受体拮抗剂；抑制豚鼠离体气管、大鼠肺、雪貂脾和绵羊支气管(pA2s=6.8-7.4)中LTD4或LTC4诱发的收缩；以0.1mg/kg的剂量抑制由卵清蛋白诱发的哮喘豚鼠模型中的气道过敏和BALF嗜酸性粒细胞浸润；增加小鼠由PTZ诱发的癫痫发作模型中全身性癫痫发作的潜伏期并降低EEG幅度。A CysLT1 and CysLT2 receptor antagonist; inhibits LTD4- or LTC4-induced contractions in isolated guinea pig trachea, rat lung, ferret spleen, and sheep bronchus (pA2s = 6.8-7.4); suppresses airway hypersensitivity and BALF eosinophil infiltration in a guinea pig model of ovalbumin-induced asthma at 0.1 mg/kg; increases the latency to generalized seizures and decreases the EEG amplitude in a mouse model of PTZ-induced seizures.分子式C27H36O5S分子量472.6CCCCC/C=C\C\C=C/C=C\C=C/[C@@H](Sc1ccc(cc1)C(=O)O)C(O)CCCC(=O)O