17-phenyl trinor Prostaglandin

【进展|热点】Immunity:IL-17A和IL-17F的表达调控机制不同

-22、IL-21以及Th17特异性的转录因子ROR-γt以及ROR-α，但是合成IL-17A的能力受损。通过观察Itk缺失的细胞对TGF-β和IL-6的反应性后，作者发现其IL-17A合成受损与细胞因子信号通路关系不大。令人感到意外的是，作者发现：采用钙通道激活剂能修复Itk缺失的细胞IL-17A合成的缺陷，而采用钙通道激活剂FK506则能使野生型Th17细胞合成IL-17A的能力受损，表现出和Itk缺失的细胞相似的表型。联系到，Itk是TCR的重要信号分子，其下游存在钙离子依赖性信号转导途径

Enzyme Immunoassay of Isoprostanes

, and excreted. It is now well recognized that isoprostane levels, most commonly those of 15F2t -isoprostane (formerly denoted 8-iso-prostaglandin F2 α ) in blood or urine, are useful biomarkers for the assessment of oxidative stress, which is a major risk factor

Measurement of 8-epi-PGF2 as a Marker of Lipid Peroxidation In Vivo by Immunoaffinity Extraction and Gas Chromatography-Mass Spectrometry

Isoprostanes (IPs) are a recently discovered complex group of stable prostaglandin-like molecules formed by the free radical-catalyzed peroxidation of polyunsaturated fatty acids (1 ). F2 -isoprostanes (F2 -IPs) are formed by the oxidation