Eledoisin

一种十一肽速激肽神经肽和NK受体激动剂；在分离的犬颈总动脉和豚鼠回肠中分别与NK1受体结合（pD₂=9.5和9.21），在分离的兔肺动脉和大鼠十二指肠中分别与NK2受体结合（pD₂=8.22和7.7），在分离的大鼠门静脉和hamster膀胱中分别与NK3受体结合（pD₂=7.11和7.06）。该化合物可诱导分离的豚鼠回肠和兔空肠收缩，诱导大鼠唾液分泌，并在体内降低兔和豚鼠的动脉血压。An undecapeptide tachykinin neuropeptide and NK receptor agonist; binds to NK1 (pD2 = 9.5 and 9.21 in isolated dog carotid artery and guinea pig ileum, respectively), NK2 (pD2 = 8.22 and 7.7 in isolated rabbit pulmonary artery and rat duodenum, respectively), and NK3 (pD2 = 7.11 and 7.06 in isolated rat portal vein and hamster urinary bladder, respectively); induces contraction of isolated guinea pig ileum and rabbit jejunum; induces salivation in rats; lowers arterial blood pressure in rabbits and guinea pigs in vivo.