Thymosin α1 (human, mouse, rat

一种免疫调节肽，由前胸腺素α裂解形成；在体外抑制5TGM1小鼠和OPM-2、LP-1、U266人多发性骨髓瘤细胞的生长，但在体内无此作用；在20µM浓度下，可增加C57BL/KaLwRij脾细胞中CD3和CD28诱导的T细胞增殖，但在C57BL/KaLwRij和BALB/c脾细胞共培养的异体混合淋巴细胞反应中无此作用；抑制高表达PD-L1的H1299、NL9980和L9981非小细胞肺癌（NSCLC）细胞的生长和迁移，但对低表达PD-L1的A549和SPC-A-1 NSCLC细胞无此作用；在L9981 NSCLC小鼠异种移植模型中，以20mg/kg/天的剂量给药可减少转移病灶数量，但在A549模型中无此效果；在CFTRF508del/F508del小鼠模型（用于模拟囊性纤维化和慢性烟曲霉菌感染）中，以200µg/kg剂量给药可增加IDO1表达和IL-10水平，同时降低IL-1β和TNF-α的产生。An immunomodulator peptide formed from the cleavage of prothymosin α; inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo; increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures at 20 μM; inhibits the growth and migration of H1299, NL9980, and L9981 NSCLC cells that express high PD-L1 levels but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels; decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model at 20 mg/kg per day; increases IDO1 expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a CFTRF508del/F508del mouse model of cystic fibrosis and chronic A. fumigatus infection at 200 μg/kg.