AZD 1283

P2Y12受体拮抗剂(IC50=25nM)；在10µM浓度下选择性结合P2Y12受体(Kd=11nM)，超过100种酶、受体和离子通道，包括P2Y1、PAF和血栓素A2受体；在改良的Folts犬血栓模型中增加血流量并抑制ADP诱导的血小板聚集（ED50s分别为每分钟3和10µg/kg）。An antagonist of the P2Y12 receptor (IC50 = 25 nM); selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes, receptors, and ion channels, including the P2Y1, PAF, and thromboxane A2 receptors at 10 µM; increases blood flow and inhibits ADP-induced platelet aggregation in a modified Folts dog model of thrombosis (ED50s = 3 and 10 µg/kg per minute, respectively).