Amyloid-β Precursor Protein (9

Development of Neoepitope Antibodies Against the β-Secretase Cleavage Site in the Amyloid Precursor Protein

A detailed understanding of the biochemical events leading to the proteolytic excision of the β-amyloid peptide (A β) from the amyloid precursor protein (APP) has eluded many researchers. This is largely because the measurement of the various APP

Interaction of the Presenilins with the Amyloid Precursor Protein (APP)

the deposition of amyloid Aβ peptide. The latter is released from its cognate amyloid precursor protein (APP) by a two-step proteolytic conversion: first, proteolysis of APP by β-secretase, which releases the N-terminus of Aβ, and second, conversion

Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins

It has been well established that β-amyloid peptide is the principal protein component of extracellular cerebral amyloid deposits in patients with Alzheimer’s disease (1 ,2 ). β-Amyloid is derived from a large precursor protein, amyloid