Tioconazole

一种咪唑类抗真菌药；抑制多种真菌的生长，包括白色念珠菌、新型念珠菌、烟曲霉和红色毛细管菌（MIC分别为4.7、0.1、5.7和0.5µg/ml）；抑制无细胞白色念珠菌匀浆中甾醇的C-14脱甲基化（IC50=50-80nM）；在2%w/v的乳膏中减少从阴道念珠菌病小鼠模型的阴道中回收的活念珠菌细胞数量。An imidazole antifungal; inhibits the growth of various fungi, including C. albicans, C. neoformans, A. fumigatus, and T. rubrum (MICs = 4.7, 0.1, 5.7, and 0.5 µg/ml, respectively); inhibits C-14 demethylation of sterols in a cell-free C. albicans homogenate (IC50 = 50-80 nM); reduces the number of viable Candida cells recovered from the vagina in a mouse model of vaginal candidiasis at 2% w/v in a cream.