Oncrasin-1

一种抗癌药物；对表达持续激活型K-Ras的肺癌细胞有活性（对H460、H2122、A549和H2887细胞的半数抑制浓度IC50分别为0.25、1、1.58和0.11）；诱导T29Kt1和H460细胞中PKCι的核聚集及细胞凋亡；在H460小鼠异种移植模型中，每天以100毫克/千克的剂量给药，可减小肿瘤体积并延长存活时间。An anticancer agent; has activity against lung cancer cells expressing constitutively active K-Ras (IC50s = 0.25, 1, 1.58, and 0.11 for H460, H2122, A549, and H2887 cells, respectively); induces nuclear aggregation of PKCι and apoptosis in T29Kt1 and H460 cells; reduces tumor volume and increases survival time in an H460 mouse xenograft model at 100 mg/kg per day .