GnRH II (trifluoroacetate salt

GnRHR激动剂；与在COS-7细胞中表达的重组人I型和狨猴II型GnRHR结合（IC50s分别为26.1和1.07nM），并刺激肌醇磷酸的产生（EC50s分别为7.41和0.45nM）；刺激培养的原代恒河猴垂体前叶细胞释放LH和FSH（EC50s分别为0.37和0.59nM）；增加白来航母母鸡血浆LH水平（1μg/kg，静脉注射）；降低斑马鱼的食物摄入量（1pmol/g，脑内注射）；增加雌性白冠麻雀的求偶行为（100ng，脑内注射）。A GnRHR agonist; binds to recombinant human type I and marmoset type II GnRHRs expressed in COS-7 cells (IC50s = 26.1 and 1.07 nM, respectively) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively); stimulates LH and FSH release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively); increases plasma LH levels in White Leghorn pullets (1 μg/kg, i.v.); decreases food intake in zebrafish (1 pmol/g, i.c.v.); increases courtship behavior in female white-crowned sparrows (100 ng, i.c.v.).