[Leu31,Pro34] Neuropeptide Y (

NPY受体激动剂；与人类Y1和Y5受体结合（Kis分别为0.11和0.17nM）；与恒河猴Y1和Y5受体结合（Kis分别为0.08和0.18nM）；降低表达人类和大鼠Y4受体的LM(TK-)细胞中福斯高林诱导的cAMP积累（EC50s分别为29.5和2.95nM）；与恒河猴Y2和小鼠Y6受体结合（Kis分别为410和9.7nM）；使大鼠心室心肌细胞的细胞蛋白质量增加25%（10nM）；增加大鼠的食物摄入量（0.7-7nmol，icv）。A NPY receptor agonist; binds human Y1 and Y5 receptors (Kis = 0.11 and 0.17 nM, respectively); binds rhesus monkey Y1 and Y5 receptors (Kis = 0.08 and 0.18 nM, respectively); reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s = 29.5 and 2.95 nM, respectively); binds to rhesus monkey Y2 and mouse Y6 receptors (Kis = 410 and 9.7 nM, respectively); increases cellular protein mass by 25% in rat ventricular cardiomyocytes (10 nM); increases food intake in rats (0.7-7 nmol, i.c.v.).