SB-742457

5-HT6拮抗剂(Ki=1.4nM)；以高亲和力与5-HT1B、5-HT2A、5-HT2B和5-HT2C受体结合；以浓度依赖性方式降低5-HT6激活Gs介导的cAMP生成(EC50=21nM)；逆转东莨菪碱引起的大鼠新物体识别缺陷和年龄引起的空间记忆障碍(1.5mg/kg)；对大鼠有饱腹作用(3.0mg/kg，腹腔注射)，与对照组相比，训练大鼠舔葡萄糖溶液时，舔舐次数减少24%。A 5-HT6 antagonist (Ki = 1.4 nM); binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity; reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner (EC50 = 21 nM); reverses scopolamine-induced novel object recognition deficits and age-induced impairments in spatial memory in rats (1.5 mg/kg); has a satiating effect on rats (3.0 mg/kg, i.p.), reducing licking bouts by 24% compared to control in rats trained to lick a glucose solution.