Methyl-β-cyclodextrin

一种随机甲基化的β-环糊精形式；已被用于改善各种化合物的水溶性；已用于从脂质膜中提取胆固醇；在5mM浓度下，降低转染有人体α-突触核蛋白的B103神经母细胞瘤细胞中膜和去污剂不溶性部分的α-突触核蛋白水平；在α-突触核蛋白病的转基因小鼠大脑中降低α-突触核蛋白水平。A randomly methylated form of β-cyclodextrin; has been used to improve the aqueous solubility of various compounds; has been used to extract cholesterol from lipid membranes; reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein at 5 mM; reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.