CPPHA

mGluR5的正向变构调节剂；增强谷氨酸、3,5-DHPG和quisqualate对人类和大鼠mGluR5的激活作用（人类和大鼠mGluR5的EC50s分别为0.316-0.5和0.634-1.16μM）；增强CA1锥体细胞中3,5-DHPG诱导的NMDA电流和STN神经元的去极化。A positive allosteric modulator of the mGluR5; potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG, and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively); potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of STN neurons.