STF-118804

一种Nampt抑制剂（IC50s=3-6nM），可阻止烟酰胺合成NAD+；以纳摩尔效力抑制多种B细胞急性淋巴细胞白血病细胞系的活力，并提高小鼠高风险急性淋巴细胞白血病原位异种移植模型的存活率。A Nampt inhibitor (IC50s = 3-6 nM) that prevents NAD+ synthesis from nicotinamide; inhibits the viability of multiple B-cell acute lymphoblastic leukemia cell lines with nanomolar potency and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia in mice.