Tigecycline

一种甘氨酰环素类抗生素；与细菌30S核糖体结合，阻止转移RNA进入，从而停止蛋白质合成并抑制细菌生长；对1,924种欧洲临床细菌分离株有效（MIC=艰难梭菌细胞毒素活性和艰难梭菌感染小鼠模型中盲肠和结肠中的孢子形成，剂量为6.25mg/kg，每天两次，持续5天）。A glycylcycline antibiotic; binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth; active against a panel of 1,924 European clinical bacterial isolates (MICs = C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection at 6.25 mg/kg twice daily for 5 days .