Homoharringtonine

一种生物碱；在无细胞试验中抑制兔网织红细胞和人类胎盘核糖体的苯基丙氨酸形成；与人类80S核糖体结合（Kd=38.8 nM）；在体外和体内降低病毒载量，并分别在猪和鸡模型中预防PEDV和NDV的严重症状；在SARS-CoV-2感染的Vero E6细胞培养上清液中，分别减少病毒产量和病毒RNA拷贝数（EC50分别为2.55和2.14 µM）；抑制人类红细胞培养中P. falciparum的生长（IC50=4 nM）；抑制Jurkat急性T细胞白血病细胞（IC50=9 nM）和K562慢性髓性白血病细胞（IC50=408 μg/ml）的增殖；减少外周白血病干细胞数量，并在慢性髓性白血病（CML）和B细胞急性淋巴性白血病（B-ALL）小鼠模型中提高存活率。An alkaloid; inhibits diphenylalanine formation by rabbit reticulocyte and human placental ribosomes in cell-free assays; binds to human 80S ribosomes (Kd = 38.8 nM); reduces the viral load in vitro and in vivo and prevents severe symptoms in porcine and chicken models of PEDV and NDV, respectively; reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s = 2.55 and 2.14 µM, respectively); inhibits the growth of P. falciparum in cultured in human erythrocytes (IC50 = 4 nM); inhibits the proliferation of Jurkat acute T cell leukemia (IC50 = 9 nM) and K562 CML cells (IC50 = 408 μg/ml); decreases the number of peripheral leukemia stem cells and increases survival in CML and B-ALL mouse models .