11-deoxy-16,16-dimethyl Prosta

11-脱氧-16,16-二甲基PGE2是一种稳定的PGE2合成类似物。它是EP2和EP3受体的激动剂。它是大鼠胃酸分泌和溃疡形成的有效抑制剂，ED50值分别为1mg/kg和0.021mg/kg。在体外，它在收缩人呼吸道平滑肌方面比PGF2α强900倍。11-deoxy-16,16-dimethyl PGE2 is a stable synthetic analog of PGE2. It is an agonist for both EP2 and EP3 receptors. It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively. It is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.