S32826

一种强效、选择性的自分泌运动因子抑制剂，可抑制重组自分泌运动因子β，IC50值为8.8nM；可抑制脂肪细胞释放LPA（IC50=90nM），并在5μM使用时使血浆自分泌运动因子活性降低57%。A potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 value of 8.8 nM; inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.