ZM 447439

AuroraB激酶的选择性抑制剂(IC50=10µM)，对AuroraC和A的抑制作用较弱（IC50分别为250和1,000nM）；已用于研究AuroraB在与有丝分裂和胞质分裂相关的分子事件中的作用；选择性抑制增殖细胞而非非分裂细胞。A selective inhibitor of Aurora B kinase (IC50 = 10 µM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively); has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis; selectively inhibits proliferating cells rather than non-dividing cells.