LY364947

TGF-βRI的选择性抑制剂，IC50值为59nM；对TGF-βRII(IC50=400nM)、p38MAPK(IC50=740nM)和MLK7(IC50=1,400nM)的抑制作用较弱；抑制TGF-β诱导的细胞生长(IC50=89nM)和Smad磷酸化。A selective inhibitor of TGF-β RI, with an IC50 value of 59 nM; poorly inhibits TGF-β RII (IC50 = 400 nM), p38 MAPK (IC50 = 740 nM), and MLK7 (IC50 = 1,400 nM); inhibits TGF-β-induced cell growth (IC50 = 89 nM) and Smad phosphorylation.