VU0155069

一种强效且选择性的PLD1抑制剂，体外(IC50=46nM)和细胞(IC50=11nM)均有效；在较高浓度下也可作为PLD2抑制剂有效(体外IC50=933nM；细胞内1,800nM)；在transwell测定中强烈抑制几种乳腺癌细胞系的侵袭性迁移。A potent and selective inhibitor of PLD1, both in vitro (IC50 = 46 nM) and in cells (IC50 = 11 nM); also effective as a PLD2 inhibitor at higher concentrations (IC50 = 933 nM in vitro; 1,800 nM in cells); strongly inhibits the invasive migration of several breast cancer cell lines in trans well assays.