CysLT2 Receptor (C-Term) Polyc

免疫原：来自人类CysLT2受体C端区域的合成肽；宿主：兔；交叉反应性：(+)CysLT1；交叉反应性：(+)人类；(-)大鼠；应用：ELISA、FC、IHC和WB；CysLT2受体结合LTD4、LTC4和LTE4，通过促进气道和肺血管平滑肌收缩、增加血管通透性和刺激粘液分泌，在哮喘中发挥主要作用。人类CysLT2受体的mRNA在肺巨噬细胞、气道平滑肌、心脏浦肯野细胞、肾上腺髓质细胞、外周血白细胞、脾脏、胎盘和脑中表达。Immunogen: Synthetic peptide from the C-terminal region of human CysLT2 Receptor; Host: Rabbit; Cross Reactivity: (+) CysLT1; Cross Reactivity: (+) Human; (-) Rat; Application(s): ELISA, FC, IHC, and WB; The CysLT2 receptor binds LTD4, LTC4, and LTE4 playing a major role in asthma by facillitating airway and pulmonary vascular smooth muscle contraction, increased vascular permeability, and stimulating mucus secretion. The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.