Phlorizin

来自苹果树皮的天然产物，通过竞争性抑制SGLT1和SGLT2来阻止肾脏和肠道对葡萄糖的吸收，从而降低血浆葡萄糖水平；在37°C下，对人类SGLT1和SGLT2的Ki值分别为140和11nMA natural product from the bark of apple trees that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through competitive inhibition of SGLT1 and SGLT2; exhibits Ki values of 140 and 11 nM, respectively, at 37°C, for human SGLT1 and SGLT2, respectively.